Springbok skipper John Smit will launch his new career as a tight head prop against Wales at the Millennium Stadium in the Invesco Perpetual series opener on Saturday.
The 78-times capped hooker is turning back the clock in a career that began as a prop for South Africa Under 21s and Natal Sharks.
Smit, who led his side to their second Rugby World Cup triumph in France in 2007, returns to the Springbok team as one of five changes from the starting line-up in their last outing against Australia on 30 August.
Brian Mujati drops to the bench to accommodate Smit on the tight head side of the front row and Bakkies Botha takes over from Andries Bekker in the second row after recovering from knee cruciate ligament damage 12 weeks ago.
The return of the 52-times capped Botha means he can extend his second row pairing record with Victor Matfield to 43 games.
Behind the scrum utility back Ruan Pienaar will fill the No 10 jersey in place of Butch James, while pacy wing duo Bryan Habana and JP Pietersen take over from Jongi Nokwe and Odwa Ndungane.
While Springbok coach Peter de Villiers has made changes to his last team, there are still 16 of the 22 that faced and disposed of Wales in the second Test in the summer. The Boks won the Prince William Cup series 2-0 with successive victories in Bloemfontein (43-17) and Pretoria (37-21).
"It wasn't a difficult selection for me to make. The players have shown they are ready to do justice to their selections," said de Villiers.
"We have picked Bakkies Botha from the start because we felt we would run a big risk if we used him as a replacement and he then broke down. We feel it is better for him to play from the start."
Smit is confident about moving across the front row and feeling comfortable and believes the experience within the Springbok ranks - the starting line-up boasts 559 caps to Wales' 489 - will count in their favour.
"It is going to be a big challenge moving to tight head prop again, but it is one I'm looking forward to. I know that Gethin Jenkins is a formidable opponent," said Smit.
"I haven't played their regularly for a number of years now, although I had a few matches at No 3 for Clermont Auvergne in France."
South Africa: Conrad Jantjes; JP Pietersen, Adi Jacobs, Jean de Villiers, Bryan Habana; Ruan Pienaar, Fourie du Preez; Beast Mtawarira, Bismarck du Plessis, John Smit (captain), Bakkies Botha, Victor Matfield, Schalk Burger, Juan Smith, Pierre Spies.
Replacements: Brian Mujati, Guthro Steenkamp, Andries Bekker, Ryan Kankowski, Ricky Januarie, Frans Steyn, Jaque Fourie.
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.