Winger Leigh Halfpenny and No8 Andy Powell have been selected for Wales on the back of some stunning performances with the Blues.
Wales have included two new caps - Leigh Halfpenny and Andy Powell - in the team to face South Africa in Cardiff.
Head coach Warren Gatland has handed the Cardiff Blues pair a dream international debut against the world champions at the Millennium Stadium.
Wing Halfpenny, still just 19 years old, caps a stunning start to his first season at senior level and becomes the 60th teenager to represent Wales.
He said: "It's a dream come true to pull on the red jersey. My parent burst into tears when I told them I was in the team. Hearing my name being read out was the best feeling ever.
"It's amazing because I grew up watching these players with two Grand Slams. Now I'm playing alongside them. I can't believe how quickly things have progressed.
"I've been playing with confidence and to get my first start against the world champions is unbelievable. Now I will do my best to give a great performance."
No8 Powell replaces the injured Jonathan Thomas to pack down alongside captain Ryan Jones and British Lion Martyn Williams in an impressive back-row trio.
It completes a long-awaited comeback for the former Wales Under-21s star who began his career with Newport eight years ago but has been hampered by two major shoulder operations in recent years since joining the Blues.
Powell said: "It's great news. There were times when I considered giving up when I had two major shoulder operations but I stuck with it and I've finally put my injuries behind me.
"I've been given the chance to play regularly at the Blues and I think I've taken my chance and played well.
"I hope to make the most of my call up. It boosts your confidence when Warren says positive things about you. I can't wait to get on the field."
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
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