Wales coach Warren Gatland named two new caps for his side to face world champions South Africa in the opening match of the Invesco Perpetual Series at the Millennium Stadium on Saturday - and handed prop Adam Jones his 50th.
Cardiff Blues duo Leigh Halfpenny (cap no 1060) and Andy Powell (cap no 1061) line-up for debuts against the Springboks and Gatland has told the pair to 'go out and enjoy themselves'.
Stephen Jones is partnered at half-back by Gloucester scrum-half Gareth Cooper, who is the incumbent in the jersey after impressing on Wales summer tour to South Africa this June, and Jamie Roberts is selected at outside-centre to form a new partnership in midfield with Gavin Henson.
IRB World Player of the year candidate Shane Williams joins Halfpenny in a back three completed by Lee Byrne and fellow nominee captain Ryan Jones switches to blindside flanker to accommodate Powell at No8 - with Martyn Williams providing the missing link in the back row.
In the second row Ian Evans is preferred to Ospreys colleague Ian Gough alongside Alun-Wyn Jones and in the front row Gethin Jenkins and Adam Jones pack down either side of Scarlets hooker Matthew Rees.
"Both of the debutants have been form players so far this season so they now get a chance to test themselves against the very best team in the world," said Gatland.
"At 19 years-old our message to Leigh has been to just go out there and enjoy himself, he needs to not worry about his opposite number, but just relax and play without fear and enjoy the experience.
"Andy Powell is a little different he has been around for a while and is an experienced head despite his lack of international caps, but he is most definitely in form. We will be looking to get the ball in his hands and see him run.
"Ryan Jones is adept on either side of the scrum, but to switch our captain does tell you a little bit about what we think of Andy.
"At scrum-half Gareth Cooper is the man in possession of the shirt after doing well for us, particularly in the second Test on tour this summer and he has been rewarded.
"In the centres Jamie Roberts and Gavin Henson form a partnership that any side would be proud of, but perhaps the most important point about this selection is the bench.
"We have plenty of talent and experience available to us to come on and change things if necessary, which was something that worked for us in the 6 Nations last season. The likes of Ian Gough, Duncan Jones, Richard Hibbard, Dafydd Jones, Dwayne Peel, James Hook and Tom Shanklin are all able to offer up something different when required."
* Leigh Halfpenny - who will be 19 years and 322 days old on Saturday - will be the 60th teenager to be capped by Wales. The last was fellow wing and Cardiff Blues player Chris Czekaj v Canada in 2005.
* It will be the first time Wales have started with two uncapped players in 28 internationals since the first Test v Argentina in 2006 when Ian Evans and Alun-Wyn Jones made their debuts.
* Leigh Halfpenny will be the 1,060th and Andy Powell the 1061st player to be capped by Wales.
* Adam Jones will be the 23rd player to reach 50 caps. He is the fourth prop to reach the milestone and will join eight other half centurions in the match day 22. They are starters Shane Williams, Stephen Jones, Gethin Jenkins and Martyn Williams and replacements Duncan Jones, Ian Gough, Dwayne Peel and Tom Shanklin.
* Jamie Roberts will be the 29th player to play in an international on his birthday - the last ones to do that were Adam Jones in Dublin this year and Tom Shanklin v South Africa on 24 November, 2007.
WALES: Lee Byrne; Leigh Halfpenny, Jamie Roberts, Gavin Henson, Shane Williams, Stephen Jones, Gareth Cooper; Gethin Jenkins, Matthew Rees, Adam Jones, Alun-Wyn Jones, Ian Evans, Ryan Jones (capt), Martyn Williams, Andy Powell REPLACEMENTS: Richard Hibbard, Duncan Jones, Ian Gough, Dafydd Jones, Dwayne Peel, James Hook, Tom Shanklin
Nearly 40 players were involved in the first Wales Under 18 training session of the season. WRU National Performance Manager Gethin Watts is excited at the potential shown by the group and expects the Regional Under 18 Championship to hone their skills even further.