Leinster, who inflicted that defeat on the Blues last Friday night in one of the highlights of round three of the Magners League, will have a third consecutive win in their sights when Llanelli Scarlets come to the RDS. Should the Irish province succeed it will give them a 17th straight home win, equalling the Magners League record currently held by the Blues.
Also on Friday night, Andy Robinson will make his debut as a Magners League Coach leading an Edinburgh side buoyed by their win over Ulster last weekend against the Ospreys, with the champions travelling north looking to build on the opening win of their title defence, against Glasgow Warriors last weekend.
After successive away defeats the Warriors will be glad to get back to Glasgow for Friday's fourth fixture. The Warriors have won their last four home games in the League, while Connacht will travel in trepidation having not won in Scotland for over a year, and having lost four of their last five games against the Glasgow side.
The final tie of the round, on Saturday evening, sees Ulster travel to Rodney Parade knowing they have won their last four games against the Newport Gwent Dragons but seeking their first away league win since early April. A defeat for the Dragons will see them set an unwelcome record for the region of four straight league defeats.