Both teams will be seeking their first win in the league after opening round defeats but Scarlets Director of Rugby Phil Davies is looking forward to the showdown.
"We had a couple of exciting games last year and hopefully this will be no different," he said. "We had a disastrous start to our game at the Liberty Stadium last season when we lost our fly half before the game and the Ospreys put a lot of points on us early on. I'm sure it will be a great occasion."
Scarlets flanker Dafydd Jones says he is ready for the test of the Ospreys in the West Wales derby.
"We know what to expect, it will be intense to say the least," he said. "It's a tough place to go but we obviously need to get points on the board after our opening defeat to the Dragons at Stradey Park.
"That was disappointing, but it has focused us, we've worked hard, and are looking forward to the challenge."
Scarlets:
15. Morgan Stoddart
14. Garan Evans
13. Regan King
12. Gavin Evans
11. Matthew Watkins
10. Ceiron Thomas
9. Gavin Cattle
1. Iestyn Thomas
2. James Hayter
3. Deacon Manu
4. Vernon Cooper
5. Adam Eustace
6. Dafydd Jones
7. James Bater (Capt)
8. Nathan Thomas
Replacements:
Bruce Douglas
Ken Owens
Lou Reed
Jonathan Edwards
Liam Davies
Darren Daniel
Jonathan Davies
