Beaten 54-7 when the sides met at Abercynon in November, the region is certainly hoping to sign off with a victory over their table-topping neighbours.
The match was originally scheduled for Eugene Cross Park, however, a replacement venue is currently being considered.
Meanwhile, the Ospreys (third) and Scarlets (second) come face to face at Waterton Cross where a victory for either side would be enough to see them through to face the Blues.
Blues High Performance Manager, Gafyn Cooper, said: "I think we have deserved our place in the final. We have lost one game out of five and have played well. I would like to think they can clinch that final spot in style."
Cooper's opposite number at the Dragons, Ron Schottle said: "It has not be a good season for us, but the side want to finish with a bang and I know they will be up for it. It should be a decent contest."
Dai Arthur, High Performance Manager at the Ospreys added: "It has come down to the last game and, in my eyes, that tells you how competitive this tournament really is. If we win we will go through. I am hoping that will be the case."
Dragons: J Burgess, C Young, K Price, G Ashman, N Preece, D Langdon, T Edwards (capt), W Griffiths, L Harward, R Cadogan, O Mayers, T Price, E Matthews, T Organ, L Dykhoff. Replacements: G Young, C Fillier, J Owen, D Morgan, S Skinner, R Turner, G Dare.
Blues: T Daley, K Hendrickson, L Thomas, T Cooper, G Jones, M Schropher, D Allinson, N Eaves, A Fowler, P Palmer, J Down, M Gardner, J Groves (capt), J Cullen, M Larson. Replacements: G Deren, H Dowden, K Jenkins, A Wilson, M Al-Azzawi, T Isaac, M Edwards.
Ospreys: J Howells, J Pike, A Wilkins, N Harwod, L Halfpenny, T Cole, R Webb, P Price, M Breeze, D Matthews, J Richards, K Maiden, J Jones, L Simms, S Kiley (capt). Replacements: C Morgan, N Roberts, L Hathaway, R Lawrence, L Elliot, R Bevington, J Griffiths.
Scarlets: Squad not announced at present