Rowland Phillips' side are nine points clear at the top of Wales' top flight and show no signs of letting their foot off the gas in their quest for glory.
Pontypool fell victim to second-placed Aberavon last weekend and are unlikely to trouble their high-flying visitors.
Struggling Ebbw Vale play host to Aberavon at Eugene Cross Park on Saturday desperate for a win to ease their relegation worries.
The Steelmen's cause wasn't helped by last week's hammering at the hands of Neath but Aberavon are unlikely to offer a reprieve.
The Wizards moved into second place with their win over Pontypool and are nine points behind Neath having played the same number of games.
Kevin Hopkins' side will need to rely on Neath losing at least three times in their remaining games if they are to wrestle the crown from the Gnoll.
Bridgend go head to head with Newport at the Brewery Field having slipped to third in the table.
The Ravens have been in contention for the title from the outset but, like Aberavon, are left hoping Neath slip for them up to be in with a chance.
Second place is still well within Chris Stephens' grasp and there is no doubt that Bridgend will end the season with a flourish.
Sixth-placed Newport would enjoy nothing more than a win over the Ravens and this game looks set to be hard fought and very close.
Bedwas front up to visiting Llandovery at Bridge Field as they seek to end the season on a high and improve on last years 13th place finish.
The Drovers meanwhile are dangerously close to the relegation places and need points if they are to avoid the drop.
Fourth-placed Pontypridd travel to Carmarthen in fourth place just three points behind Bridgend and Aberavon.
Simon King's outfit are already assured of beating last season's 10th place and could still mount a late bid for second place.
Carmarthen need points as they teeter dangerously close to the drop zone but are unlikely to receive any favours from a determined Pontypridd.
Glamorgan Wanderers find themselves in the fight to avoid the drop and entertain Swansea on Saturday while at Llynfi Road Maesteg clash with Cross Keys.