The Blues South are currently sitting in third place - having played a game more - some four points behind the Dragons. Victory for them would change things dramatically whilst making life far more difficult for the Dragons.
No.8 Craig Filier will lead the Dragons tonight as they go in search of a fifth win in six games.
The other game sees the Blues North, who are fourth with 12 points, take on the Scarlets who are rock bottom with only three points from their half dozen matches. That game has been switched from Aberdare to Ynysybwl.
Another win for the North would keep them in the hunt providing the South defeat the Dragons.