Despite Calzaghe's withdrawal, Frank Warren's super-show at the Millennium Stadium will still go ahead with a superb six-title fight card including the highly anticipated Heavyweight rematch between Danny Williams and Matt Skelton, Swansea's KO king Enzo Maccarinelli leads the Welsh charge along with the explosive shoot-out between Gary Lockett and Ryan Rhodes for the WBU Middleweight title.
Newport's Bradley Pryce defends his Commonwealth crown and Tony Doherty and Taz Jones once again square off for the Celtic championship, which ended in such controversial circumstances last time. The Millennium Stadium will also see the return to Welsh soil of boxing's hottest young prospect Amir Khan.
Promoter Frank Warren said, "Like everyone else involved in the promotion, I am really disappointed that Joe has had to withdraw because of this latest injury. After medical consultation he has been advised to rest so we are looking at Joe returning to action in the autumn.
"Although Joe's withdrawal is a blow, I'm delighted to say that the show will still go ahead and we have a fantastic line up at the Millennium Stadium with Williams v Skelton, Maccarinelli, Rhodes v Lockett and young Amir plus a top quality undercard. This is still a massive, massive show and I am sure the stadium will still witness Wales's greatest ever boxing show."
Paul Sergeant, Millennium Stadium, chief executive, "We are aiming to meet with the promoters as soon as possible to establish details of the July 8 event now Joe is not available.
"It's disappointing for everyone that Joe will be unable to fight but even more devastating for Joe himself and we look forward to welcoming him back for a re-scheduled fight in front of his home crowd when he's back fighting fit."
Ticket-holders who attend the Millennium Stadium on 8th July will be given an added incentive as, if they retain their used ticket, they will be given a voucher that will entitle them to a 10% discount on a ticket for Joe Calzaghe's ring return in the autumn.
Please be advised that there will be deadline of 7 days from today for all refund requests to be lodged at the respective point of purchase. Any request for refunds after the 9th June will be declined.