Blues Regional High Performance Manager Gafyn Cooper said, "It has been a terrific start to the season for all three of the Blues sides and we have been delightyed with the way in which they have opened up.
"This contest will be as tough as any because the Ospreys are not only the reigning champions but possibly the favourites to win it again. Still, confidence is high within the Blues squad and it should be another excellent contest in what is turning out to be another outstanding competition."
In the other game, the Dragons take on the Scarlets with both sides seeking a first win of the season. The Dragons should be at full strength whilst the Scarlets are likely to be missing prop Hugh Gustafson amongst one or two others.