Victory this evening will take them at least five points clear with only one round of pool games remaining.
The other game sees the Scarlets at home to the Dragons who have yet to win a game. The Scarlets, who have 12 points from their four games to date, will be hoping for maximum points against a Dragons side who have picked up only one point so far this term.
Ospreys: J Howells, L Halfpenny, J Pike, A Wilkins, D Thomas, M Roberts, C Morgan, R Bevington, R Lawrence, L Elliot, J Griffiths, K Maiden, S Kiley, L Sims, R Pitman
Replacements: R Webb, T Cole, S Robinson, M Breeze, J Jones, P Price, J Richards
Blues: K Baller, G Jones, L Thomas, T Cooper, J Egan, L Ford, T Isaacs, N Eaves, A Fowler, P Palmer, M Alazawi, J Down, J Groves (capt), A Wilson, M Larsen
Replacements: L Scarfe, B Warburton, H Dowden, K Jenkins, S Thomas, J Bull, M Gardner