Also on Friday night two sides with title aspirations meet at Murrayfield as fourth placed Ulster face Edinburgh Gunners who are only two points ahead of them in third. Ulster are a bit of a hoodoo team for the Gunners who having won only once in eleven meetings between the sides.
The three remaining games are on Saturday with leaders Munster at home to Glasgow. The Warriors beat Munster ah home in something of a shock earlier in the season but face the daunting task of travelling to Limerick, with the leaders having lost only once in their last 25 home games in all competitions.
Second placed Leinster visit Newport to face the Dragons, and they will travel with trepidation having lost on both trips to Wales this season. The Dragons have won their last three and could make a significant move up the table if they make it a third defeat in Wales for the Dubliners.
The final game sees Scarlets travel to basement side Connacht. The west of Ireland province are 11 points adrift at the foot of the table and the Scarlets, who have two games in hand over the four teams above them would keep their title hopes very much alive with a win in Galway.