The Queen of Pop is set to perform at only two UK venues and will kick-off the European leg of her world tour at Cardiff's iconic venue, which is quickly becoming the premier European live entertainments venue.
Madonna's history towers over the chronicles of popular culture across the world, comprising a list of First, Best, Fastest and Longest.
Madonna has broken every available radio, video, sales and box-office record - indicative of her vast fan base.
With such a fan base, the Millennium Stadium could be filled three times over!
"This is a major coup, when we found out that Madonna wanted to play here we knew this would be huge," said Paul Sergeant, Chief Executive Millennium Stadium.
"Being one of two venues in the UK to have Madonna perform at is a real honour; this is a guaranteed spectacular experience for everyone involved.
"We are delighted to have such an icon play at the Millennium Stadium and it is fantastic that we as a venue have been chosen to open Madonna's European leg of her World Tour.
"This announcement highlights our reputation amongst top music promoters and recognises how highly we are regarded in the music industry and on a world wide scale."
Tickets go on sale Friday, April 21 at 9.00am and are priced from £80 to £160, limited to six per person (all tickets are subject to booking fee).
Tickets are available to buy at Cardiff International Arena or online www.getLIVE.co.uk or by calling the ticket hotline on: 0871 230 5441(24 hrs)