Konica Cup semi-finalists Maesteg meanwhile could use a win to steer them clear of the relegation battle although they hold two games in hand over both Pontypool and Llandovery.
Ebbw Vale go head to head with Pontypool at Eugene Cross Park in a crucial clash for both relegation-stricken clubs. The Steelmen currently prop up the top flight but hold a game in hand over the teams above them. A win on Saturday could prove crucial to their chances of survival while a defeat could leave them up to six points adrift at the foot of the table if Llandovery also win. Pooler fell victim to Cardiff's great escape attempt last time out and desperately need points if they want to be playing premiership rugby next term.
Newport make the trip to Pandy Park to front up to Cross Keys with the teams side by side in the table although Newport have three games in hand. The Black and Ambers could still catch Llanelli in fifth if they win their games in hand but will not better or equal last season's second place.
At St Helens Swansea welcome Welsh Cup holders Llanelli with relegation worries long forgotten and a mid-table finish in their sights. Llanelli meanwhile are too far adrift to make an assault on the teams above them but could still claim fifth spot to cap a respectable season.
Glamorgan Wanderers entertain Cardiff at the Memorial Ground with confidence at a high following their 15-31 demolition of Cross Keys last weekend. The Wanderers came from 15-12 down at half time to stun the Keys and prove that they are worth their position in the Welsh Premiership. A similar display against the Black and Blues would confirm that the Wanderers are here to stay - and not just to make up the numbers.
At Church Bank struggling Llandovery take on Carmarthen knowing that points are now vital if they are to avoid the drop and Pontypridd play Bedwas at Sardis Road.