Captain Mel Berry, and Vice-Captain Clare Flowers, also return to Six Nations action after a break, with hooker Jamie Kift, back row Dawn Mason and outside-half Naomi Thomas coming back to bolster the ranks.
An element of youth will also be present in the shape of UWIC's Philippa Tuttiett and Rhian Bowden who will be hoping to make their debuts as Wales move to improve vastly on last year's 81-0 defeat.
Kerry Jenkins (knee) and Amy Thompson (shoulder) are unavailable for selection due to injury.
Head Coach, Fielies Coetsee, is confident that Wales can put on a show in England "We've had a very positive build-up to the competition, with some real talent showing through during training. We were fortunate to be able to select a side that has a balance of experience and youth; a combination that we are sure will allow us to put in a strong performance."
Wales Senior Squad from:
Mel Berry (Worcester); Rhian Bowden (UWIC); Amy Broadstock (Llandaff North); Rachel Brown (Waterloo); Liza Burgess (Clifton/Tylorstown); Jenny Davies (Caernarfon); Amy Day (UWIC); Claire Donovan (Saracens); Non Evans (Clifton/Tylorstown); Elen Evans (Dolgellau); Clare Flowers (Clifton/Tylorstown); Claire Horgan (Waterloo); Louise Horgan (Saracens); Jamie Kift (Clifton/Tylorstown); Dawn Mason (Richmond); Catrina Nicholas (Cardiff Quins); Rachel Poolman (UWIC); Louise Rickard (Saracens); Naomi Thomas (Clifton/Tylorstown); Philippa Tuttiett (UWIC); Rhian Williams (Wasps); Kylie Wilson (Waterloo)