The Scarlets are currently five points clear at the top of the table with 15 points from their three games. The Ospreys have 10 from their three and will be hoping to close the gap. However, the Scarlets appear to be unstoppable and they have once again selected a side brimming with international talent.
Darryl Hill, high performance manager for the Scarlets' region, said, "The side has had a break over Christmas but we are right back into it now with a very difficult game against the Ospreys.
"Home advantage has been key throughout the competition and I know that they will look to use that in their favour."
Dai Arthur, regional high performance manager for the Ospreys, said, "We were delighted to win the first of the finals last Friday and I know that the guys will be keen to win this one and put pressure on the Scarlets. Having said that, they are not the only unbeaten side in the table for nothing."
Scarlets: M Thomas; Alec Jenkins, J Davies, J Taffetsauffer, M Davies R Priestland, D Allinson H Gustaffson, K Owens, C Cross, K Davies, L Reed, J Turnbull, S Phillips, L Williams Replacements: J Charlton, R Thomas, S Martin, D George, T Slater, Alex Jenkins, D Griffiths
Ospreys: L Bevan; J Pike, A Wilkins, L Ryland, N Roberts; J Spratt, L Gunnell, N White, M Breeze, Roy Jones, S Kiley (Capt), D Phillips, L Jones, R Gallagher, A Gwynne Replacements from: Rhodri Jones, N Boyce, D Lloyd Jones, S Leach, S Allen, A Rogers, C Barkley, K Passmore