Ruddock goes into the match without first-choice midfield pairing Gavin Henson (groin) and Tom Shanklin (knee), while leading contender Sonny Parker is battling a hamstring injury. The Blues' Jamie Robinson is still finding his feet after a year out with a knee injury and the Dragons' Hal Luscombe is out of the equation after breaking a thumb against Edinburgh on Friday night.
Ruddock has the choice of the Dragons' Ceri Sweeney in the No. 12 jersey, while veteran Mark Taylor may earn a recall if Parker fails next week's fitness test. Skipper Gareth Thomas played at outside centre for Toulouse on Saturday and may move from fullback to fill the problem area.
World-class prop Gethin Jenkins (shoulder) will also miss the autumn Test series, while doubts linger over Lions star Ryan Jones after he injured a shoulder against Bath a week ago. Ironically, the man in the Bath No. 8 jersey that day is being tipped as Jones's replacement in the Wales lineup.
Gareth Delve has been tipped as a Wales star for several years, but a serious shoulder injury meant his 2003 match against the Barbarians is his only match in the red jersey. But after an eye-catching performance in Bath's Powergen Cup victory over the Ospreys, his name is back in the headlines.
"I got a text from Scott Johnson after the Ospreys game, asking if Gareth was available for Wales squad training," Bath coach John Connolly said. "Gareth is a big, strong man. He's incredibly athletic, he's a massive ball-carrier, a good defender and he has the physicality for Test rugby.
"I think Gareth will be involved in the autumn. Ryan Jones is a good player, but he took another knock against us so you don't know. And Colin Charvis is competing with Gareth - I think Charvis is an openside flanker. I think you'll see Gareth in the 22 for the autumn Tests."
Connolly said the most exciting thing about Delve was that he still had a lot of improvement in him after his horror run of injuries.
"Gareth is definitely on an upward spiral - he didn't play for three years and it's always going to take a year to come back into it," the Australian said. "He came into some form slowly last year and he's really stepping up to the mark this season. Against the Ospreys, he was the best backrower, and the best thing is that you know he has a lot of improvement in him."
GB7s women left their England base to train in Wales this week. Olympic Games hopeful Rachael Burford gives WRU TV's Graeme Gillespie her thoughts on Welsh teammate Jasmine Joyce - a 'one touch wonder'
The GB7s women's squad is currently training at Wales' Centre of Excellence where assistant coach Richie Pugh tells WRU TV's Graeme Gillespie some 'tough calls' will have to be made when it comes to finalising the 12 spots for Rio's Olympic Games.
Wales U20's Billy McBryde is looking forward to starting his first game against New Zealand this afternoon in the World Rugby U20 Championship where his side are looking to gain revenge from last week's pool defeat to the Kiwis.