With five consecutive wins at home under their belts the Scarlets will be pushing for a top four place when Glasgow come to Stradey on Saturday, however the Gwent Dragons will also have top four aspirations when they face Edinburgh. The Scots have won five of their last six Murrayfield games and will also be desperate to win and keep their own cup hopes alive.
Elsewhere it's a battle to make a top eight finish and when the round kicks off at The Arms Park on Friday evening both the Blues and Ulster will harbour cup hopes. Defeat for the home side will end their knock out chances and leave Ulster ideally placed for a cup spot.
Connacht will not only have Celtic Cup but also Heineken Cup qualification on their mind when the Ospreys come to Galway. This is the Champions' last regular league game and amazingly they have never beaten Connacht in any of their three previous meetings!
The final game of the round sees the Borders, now unable to reach the knock out competition, face Munster, who are already guaranteed a home draw, at Netherdale.