It should be interesting to see if Bedwas can take a quick double or whether the Sardis Road supporters can pull Ponty through.
Leaders Neath go to Pontypool mindful of a beating there at the end of last season. Another such result would be harmful to title hopes as Newport are on a roll, though they will have to contend with a lively Carmarthen Quins side, who have centre Emyr Jones on 99 career league tries. Newport need three tries for 1,000 in league rugby.
Caerphilly are still fighting to avoid relegation and if they can beat Llandovery, they will have a very faint chance, while relegated Newbridge are not playing and Llanharan, also doomed, are at Ebbw Vale.
Swansea against Bridgend is sure to bring a host of points at St Helen's and Aberavon would like to defeat Cross Keys a week before a semi-final cup appearance.
The annual Women's club launch was held at the Wales Centre of Excellence where National Women's Head Coach and Programme Lead Rhys Edwards, Competition Secretary Adrian Howell and Cardiff Met player Ffion Jones express eagerness for the new campaign to get under way.
WRU TV follows Wales' RWC training squad on day one of their camp in North Wales. The squad were greeted to an official welcome in Colwyn Bay and then headed for an afternoon of team building at ZipWorld