It should be interesting to see if Bedwas can take a quick double or whether the Sardis Road supporters can pull Ponty through.
Leaders Neath go to Pontypool mindful of a beating there at the end of last season. Another such result would be harmful to title hopes as Newport are on a roll, though they will have to contend with a lively Carmarthen Quins side, who have centre Emyr Jones on 99 career league tries. Newport need three tries for 1,000 in league rugby.
Caerphilly are still fighting to avoid relegation and if they can beat Llandovery, they will have a very faint chance, while relegated Newbridge are not playing and Llanharan, also doomed, are at Ebbw Vale.
Swansea against Bridgend is sure to bring a host of points at St Helen's and Aberavon would like to defeat Cross Keys a week before a semi-final cup appearance.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.