There will be five rearranged matches played as clubs take advantage of being knocked out of the cup. Leaders Llangennech face a difficult task as they entertain third-placed Whitland, while Maesteg will be poised to take advantagwe of any slip if they can overcome UWIC at Cyncoed.
Narberth at last get back into action as they entertain an ailing Carmarthen Athletic at the Lewis Lloyd Ground, while Fleur de Lys bring forward their match with Builth Wells from February 23 and Bonymaen will be the visitors at Tonmawr.
Two of the deignated fixtures will not be played as Llantwit Fardre (home to Croesyceiliog) and Banwen (away to Cwmllynfell) are still involved in cup action. However, there will be twelve matches evenly spaced between West and East.
In the East, Ystrad Rhondda go to Treorchy and Newport Saracens entertain Brynithel, while West leaders Waunarlwydd visit bottom club Tondu. Tight matches should be between KIdwelly and Dunvant and at Llantrisant, where 'The Black Army' take on Abercynon.
Bargoed and Blaina were promoted together last season and at Central Park, Blaina will be attempting to halt Bargoed long-standing unbeaten tag. While this is the top match in the East there will be a huge battle at Bailey Park as Abergavenny take on Pill Harriers.
Another unbeaten club, Rhydyfelin, entertain Tylorstown in the South-East, where North Walians Ruthin will be in action at Abercwmboi and in the South-West, leaders Maesteg Quins go to Skewen and at the bottom, pointless Glynneath are at home to Kenfig Hill. In the West, Loughor face a severe test at Pembroke Dock Quins as Gorseinon travel to Llanelli Wanderers and Aberyswyth meet Lampeter.
There are no clubs unbeaten in any of the five sections of Division Four and the five leaders are likely to stay in front after this round of games, but there are only four designated Saturday fixtures remaining in all but the Northern section. In the East, leaders Pontllanfraith are at home to Newport HSOB and in the West, Amman Utd take a five-point lead to Gowerton, where Laugharne have a big game against Cefneithen.
Fairwater make the short trip to Llandaff North in the South-East and in the South-West, Resolven take an eight-point lead to Heol y Cyw, while North leaders Llangefni are home to Denbigh as Mold travel to Llandudno.
Nantyglo are expected to extend their 16-match unbeaten run in the East as they are at home to RTB (Ebbw Vale), while there will be an important match at Tremorfa Park in Cardiff as St Alban's take on Machen. In the West, leaders Pembroke entertain St David's, while Penygroes and New Dock Stars face a tight game.
South wales Police, Cilfynydd and Cefn Coed all have 12 wins in the South-East, but all three would expect wins this weekend with Porth and Penallta hoping to make ground before the end of the season, though the latter have a bye this time. Abercrave head the South-West by seven points and are at home to third-placed Crynant, while Birchgrove, in second, take on Pontardawe.
In the North there will be the biggest match of the five sections as Bala take on Bethesda in what could be a title decider.