Top match is likely to be at the Memorial Ground in Cardiff as third-placed Glamorgan Wanderers entertain second-placed Llangennech, while top club Maesteg entertain bottom club Brynmawr in what may be a one-sided affair.
The Wanderers are on a five-match unbeaten run since November and only lost 14-10 away to Llangennech in October, but the West Walians have not lost in their last seven outings and kicker Mark Jones is back on song.
With four clubs to be relegated the Tonmawr versus Blackwood and Bridgend Athletic versus Fleur de Lys games are key ones, but the most entertaining is liable to be at Narberth where visitors UWIC are totally out of form at present.
Beddau and Whitland could be a close affair with both having good seasons and Builth Wells and Bonymaen meet in a mid-table match where little quarter is likely to be given.
Ystrad Rhondda against Llantwit Fardre in the East is a big promotion match, but Newport Saracens will be concentrating their efforts on winning at Tredegar. Meanwhile, Rumney are on a strong run and battered Treorchy 78-5 in midweek to go into the top four. They visit an ailing Llantrisant while Merthyr against Treherbert should also be a hard battle.
West leaders Waunarlwydd slipped badly at bottom club Tondu last time out. They now go to Cwmavon - another banana skin - while Cwmllynfell are at Mumbles and powerful match could be at Corus as they take on a lively Kidwelly, inspired by former Bridgend and Dunvant coach Brian Powell.
Unbeaten Bargoed surge on towards a possible second successive title in the East as they entertain Llanishen, who may have left a promotion push just too late this season. A big game in that division is the one between Old Illtydians and Abergavenny at Rumney Park on the west of Cardiff.
In the west, Loughor take on Haverfordwest, while Gorseinon will have a tough task as they meet Pemroke Dock Quins and in the South-East the unbeaten leaders Rhydyfelin go to the Reservoir Ground in Barry and rivals Mountain Ash take on the unpredictable Pentyrch.
Vardre pounded Bryncoch 29-12 in midweek in the South-West and they travel to bottom club Glynneath, who have improved recently, but still not won a game. Top club Maesteg Quins take on lowly Ystalyfera and the Aberavon Quins-Alltwen game should be the closest.
There are no unbeaten clubs remaining in the five sections of Division Four, but the game of the day will be at Aberdare where the South-East leaders Fairwater are the visitors. Penarth could catch up if they can win on a difficult trip to Rhigos.
In the West, the meeting of Amman Utd against Laugharne could well decide the title and Cefneithin against Neyland is another key clash. It's a top-dog meeting in the East also as Trinant aim to knock down leaders Pontllanfraith and in the North as top club Llangefni sit it out, Mold meet Colwyn Bay.
Resolven in the South-West should get over Pyle and will be hoping that second-placed Tonna slip up against the improving Heol y Cyw side.
Nantyglo are the first club crowned as champions in Wales. Their 17 straight wins have already secured the East title and they travel to Caldicot, while the fight is now for second spot where St Alban's will be pressed by Abertillery BG at Cardiff's Tremorfa Park.
Pembroke top the West and go to bottom club Llanybydder, while in the South-West there is a similar tale as bottom club Pontardawe face top club Abercrave.
Five clubs are battling for the South-East title and the biggest clash is at Cilfynydd, as they take on in-form Porth Harlequins as South Wales Police, Penallta and Cefn Coed all look set for victories.
Bala are nearly home for the title in the north, but meanwhile have to win at Rhayader, while Bethesda face a trip to Machynlleth.