Full-back Davies picked up a knee injury in the 20-16 defeat to the Blues on Wednesday while Thomas is out of the reckoning with back trouble. The match at the Racecourse Ground in Wrexham will be the Scarlets' third outing in eight days but director of rugby Gareth Jenkins believes his squad will be able to cope.
"We've been able to balance our selection so hopefully we won't be affected too much by the injuries," he said. "We've taken a few casualties and that might pressurise our selection, but we knew this was in front of us and we were quite clear about what this week meant."
Connacht beat the Blues at home in their first game of the season, but will arrive in North Wales on the back of a 34-3 defeat to Edinburgh Gunners.
"They'll be resilient and tough, and will make life really awkward for us," added Jenkins. "They will probably be fresh and they are always capable of tripping sides up."
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.