Flanker and captain Simon Easterby and Tonga lock Inoke Afeaki also get a break after international duty. The Scarlets need a win at Stradey Park to ensure qualification for the Powergen Cup semi-finals. And Peel said: "The pressure's nothing new for us, we enjoy playing the English and want to make the next round."
Scarlets hooker Aled Gravelle, who will start among the replacements, expects the usual challenge from across the border.
"Sale have a juggernaut pack and are good in the tight, like all English clubs," Gravelle told BBC Sport Wales. "But we'll do our best to counter them and get that semi-final spot."
Sale, who are top of the English Guinness Premiership, are expected to name a largely second-string side for their visit to south Wales.
Scarlets: Barry Davies; Mark Jones, Dafydd James, Regan King, Garan Evans; Mike Hercus, A N Other; Dorian Williams, Matthew Rees, John Davies, Hottie Louw, Adam Jones, John Mills, Alix Popham, Gavin Thomas
Replacements: Ricky Davies, Aled Gravelle, Vernon Cooper, Chris Wyatt, A N Other, Geraint Bowen, Matthew Watkins