The action kicks off with Ulster, a point behind leaders Munster, facing The Ospreys at Ravenhill. The Ulstermen have won their last 11 games at home and have lost only once in the Celtic League this season, while The Ospreys have had a wretched start to their title defence. Form would suggest that should Munster slip up in Cardiff then Ulster could go top.
However that Munster trip to the Blues could see the Irish side maintain their fine early season start - but to do that they will need to break their duck at the Arms Park where they have lost four times in the past.
Also on Friday Connacht face the Glasgow Warriors with both sides struggling to find some form in the league. Although the Irish province achieved back to back wins in the European Challenge Cup they are looking to halt a run in the Celtic League which has seen them slip to six successive defeats, while the Warriors have not won any of their last five games.
Sunday's first game sees Leinster return to Donnybrook after two games at the RDS to face Edinburgh Gunners who, despite their high league position, have failed to click away from Murrayfield. A win will see the home side leapfrog the Gunners as both sit on 22 points in third and fourth place respectively.
The round ends with Border Reivers travelling to Newport-Gwent Dragons. Despite occupying fifth place, six points ahead of the Dragons, the Border's team has never won in Wales and the Dragons will be looking to kick start their campaign in what is remarkably only their second home game of the season in the Celtic League.
Wales head coach Warren Gatland and captain Sam Warburton say their first prioirty on Sunday in the opening game of the World Cup is to win against Uruguay and not get overly concerned with points difference.
With only days to go until the biggest rugby competition in the world begins, rugby fans visiting Cardiff this autumn will be able to enjoy a special display at National Museum Cardiff as part of the celebrations surrounding the Rugby World Cup.
Geraint John has taken up the new role of WRU elite coach development manager having arrived in Wales last week. WRU TV caught up with him at the WRU rugby department's strategy day at the Millennium Stadium.
The entire Welsh Rugby Union Rugby Department gathered at the Millennium Stadium earlier this week where WRU Head of Rugby Josh Lewsey looked back on a year where structural and strategic changes have seen significant progress made
The Welsh Rugby Union has released a specially produced video to spearhead a new campaign to help promote the values of rugby union. The video, entitled Let us Play underpins the WRU rugby department's philosophy - to engage, transfer and retain players, coaches and referees.