The action kicks off with Ulster, a point behind leaders Munster, facing The Ospreys at Ravenhill. The Ulstermen have won their last 11 games at home and have lost only once in the Celtic League this season, while The Ospreys have had a wretched start to their title defence. Form would suggest that should Munster slip up in Cardiff then Ulster could go top.
However that Munster trip to the Blues could see the Irish side maintain their fine early season start - but to do that they will need to break their duck at the Arms Park where they have lost four times in the past.
Also on Friday Connacht face the Glasgow Warriors with both sides struggling to find some form in the league. Although the Irish province achieved back to back wins in the European Challenge Cup they are looking to halt a run in the Celtic League which has seen them slip to six successive defeats, while the Warriors have not won any of their last five games.
Sunday's first game sees Leinster return to Donnybrook after two games at the RDS to face Edinburgh Gunners who, despite their high league position, have failed to click away from Murrayfield. A win will see the home side leapfrog the Gunners as both sit on 22 points in third and fourth place respectively.
The round ends with Border Reivers travelling to Newport-Gwent Dragons. Despite occupying fifth place, six points ahead of the Dragons, the Border's team has never won in Wales and the Dragons will be looking to kick start their campaign in what is remarkably only their second home game of the season in the Celtic League.
Wales Head Coach Rob Howley talks to WRU TV's Sebastian Barrett about the 36-man squad he has just named for the forthcoming Under Armour series, which includes two uncapped players, Ospreys duo Sam Davies and Rory Thornton.
Head coach Rowland Phillips is deligthed he can now call BT Sport Cardiff Arms Park home for his Wales Women's side, who launch their international season next month with games against Scotland and UK Armed Forces in the heart of the capital city.
Wales Sevens star Sam Cross has put his home town club of Brynmawr on the map after winning a silver medal at the Rio Olympics with Team GB. His club have now honoured him by naming their players bar after him, as WRU TV discovered at the official launch, recently.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.