The action kicks off with Ulster, a point behind leaders Munster, facing The Ospreys at Ravenhill. The Ulstermen have won their last 11 games at home and have lost only once in the Celtic League this season, while The Ospreys have had a wretched start to their title defence. Form would suggest that should Munster slip up in Cardiff then Ulster could go top.
However that Munster trip to the Blues could see the Irish side maintain their fine early season start - but to do that they will need to break their duck at the Arms Park where they have lost four times in the past.
Also on Friday Connacht face the Glasgow Warriors with both sides struggling to find some form in the league. Although the Irish province achieved back to back wins in the European Challenge Cup they are looking to halt a run in the Celtic League which has seen them slip to six successive defeats, while the Warriors have not won any of their last five games.
Sunday's first game sees Leinster return to Donnybrook after two games at the RDS to face Edinburgh Gunners who, despite their high league position, have failed to click away from Murrayfield. A win will see the home side leapfrog the Gunners as both sit on 22 points in third and fourth place respectively.
The round ends with Border Reivers travelling to Newport-Gwent Dragons. Despite occupying fifth place, six points ahead of the Dragons, the Border's team has never won in Wales and the Dragons will be looking to kick start their campaign in what is remarkably only their second home game of the season in the Celtic League.
The Webb Ellis Cup visited Lampeter on Monday to recognise the fact that the town is celebrating a major milestone as it is believed the first ever game of rugby played in Wales, was in fact played in Lampeter 150 years ago.
Cardiff Blues U18 Girls will go into Sunday's Gemau Cymru with an extra spring in their step after Welsh internationals Elinor Snowsill and Philippa Tuttiett offered some last minute tips at a training session earlier this week.
Rob Howley and Josh Lewsey addressed more than 250 community club coaches and referees at the first WRU National Community Conference on the weekend. The volunteers benefitted from coaching masterclasses and workshops in a bid to connect all levels of the rugby pathway in Wales.
UEFA has today confirmed the Football Association of Wales (FAW) has been successful in its bid for the Millennium Stadium to host the 2017 UEFA Champions League Final on Saturday 3rd June, 2017 (kick-off: 19.45hrs GMT).