Louise Horgan is joined by her twin sister Claire and Eirlys Lougher in the front row, with Amy Broadstock and Jenny Davies taking places on the bench.
New squad members Hannah Torangi and Beth Hawke take places in the second row, with fellow youngster Amy Thompson behind them with Mel Berry and Kylie Wilson.
A changed half back pairing has been selected in the shape of Becky Davies and Awen Thomas, alongside a backline of Manon Williams, Clare Flowers, Rhian Williams, Rachel Poolman and Philippa Tuttiett.
Assistant Coach, Jason Lewis said "The team represents an excellent blend of experience and youth. Following our success in Treviso, this game gives us the opportunity to view the squad again and will provide us with a clear picture of our strength going into the Six Nations."
The fixture will take place at Saracens RFC's Bramley Road ground, kicking-off at 1pm.
Wales XV Team (1 to 22)
Louise Horgan; Eirlys Lougher; Claire Horgan; Hannah Torangi; Beth Hawke; Amy Thompson; Mellissa Berry; Kylie Wilson; Becky Davies; Awen Thomas; Manon Williams; Clare Flowers; Rhian Williams; Rachel Poolman; Philippa Tuttiett
Caryl Thomas; Jenny Davies; Amy Broadstock; Claire Donovan; Catrina Nicholas; Non Evans; Louise Rickard