Maesteg and Llanharan continue their battle for the title as Maesteg have their penultimate fixture at bottom club Tondu, who have conceded over 1,500 points in 28 matches, and Llanharan go to Parc Mawr to meet Bonymaen, knowing they have 13 tries to catch up.
UWIC and Glamrgan Wanderers play their final match at Cyncoed, while t6hird-placed Whitland entertain neighbours Carmarthen Athletic and Narberth's Otters face a visit to Llangennech. There will be a basement battle at Tredegar, who entertain Rumney, while Brynmawr meet Blackwood and Treorchy face Beddau at The OvaL.
Builth Wells are at home to Llantrisant and Fleur de Lys visit relegation-battling and injury-hit Rhymney in the East with Merthyr's bid for promotion continuing at home to Risca. Hirwaun go to Penygraig in search of a huge win; Llantwit Fardre meet a Dinas owys side that leaked 83 points on Tuesday at Fleur de Lys and the Croesyceiliog-Abercynon clash could be a fine match.
In the West, Cwmllynfell aim for a quick double over Pencoed; leaders Tonmawr face a hard match at Waunarlwydd and Bridgend Athletic face a problem at free-scoring Felinfoel. At the bottom, Birchgrove face Newcastle Emlyn and Aberavon Quins travel to Cwmavon, while Dunvant hope to resist Cardigan and must make progress at home to Corus.