Fifth-placed Carmrthen Quins may take the chance to leap over Aberavon if they can resist the challenge of struggling visitors Pontypool to Carmarthen Park.
It is the battle at the bottom of the table though, that will take centre stage.
Llanelli, propping up the division, play hosts to Cross Keys, while Llandovery have to attempt to halt a run of seven matches without a win, as they entertain Ebbw Vale, who are just two points above the Drovers.
Swansea coach Tony Clement is still aiming for a top-six finish and they could go even higher as they have six matches to play.
Visiting Newbridge are desperate for a win however and Clement's former international colleague Mike Watkins will be driving his Newbridge side hard.
Cardiff take on Bedwas at the Arms Park in a 2.30pm start, despite the nearby semi-finals. Bedwas chairman Peter Rawlins and secretary Weldon Davies are among the many ex-Cardiff men at the club and they will be all out to avenge a Cardiff win by 25-21 at Bedwas last November.