There will be ten changes, two positional, in the Wales side with new caps in centre Luke Knight and loose head prop Rhys Gill.
There also will be a new captain, as lock Bradley Davies takes over from hookers Dan George and Ross Johnston, who have both lead the side this season.
The Wales side is: A Bramwell (Neath Coll); R Owen (Colston's), M McLean
(Glantaf), L Knight (Cwmcarn HS), M Johnstone (Cwmcarn HS); E Williams
(Coleg Sir Gar), T Dickens (St David's Coll); R Gill (Cymer), D George
(Llandovery Coll), D Thomas (Llandovery Coll),
A Andrews (Woodehouse Coll), B Davies (Coleg Morgannwg, captain), A Powell
(Neath Coll), A Murphy (Cardinal Newman RCS), L Isaac (Llantwit Major CS).
Replacements: M Roberts (Neath Coll), J Roberts (Glantaf), G Williams-Davies
(Cowbridge CS), R Johnston (Bryncelynnog CS), L Williams-Jones (Brynteg
CS), R Jones (Brynteg CS), L Probert (Cantonian HS).