Division One Leaders Maesteg hope to recover their form in the visit to Beddau, but are likely to find that the home side are one of the best in the division with fly half and coach Brett Davey inspiring them.
Even a second successive loss would still leave Maesteg in front however, with Glamorgan Wanderers and Llangennech six points adrift, though both look to have comfortable home games against Tonmawr and Brynmawr respectively.
Pick of the other games is likely to be at windy Parc Mawr, where improving Bonymaen will take on a UWIC outfit who will be without the Carmarthen Quins halves Aled Thomas and Wayne Evans. Narberth will take encouragement from last Saturday's win over Maesteg as they travel to Builth Wells; Carmarthen Athletic go to out-of-form Fleur de Lys and Whitland in fifth place meet Blackwood at
Parc Llwyn Ty Gwyn.
Division Two. Two former players, Emyr Lewis and Jason Hyatt, will clash in the top match of the West as they coach Felinfoel and leaders Waunarlwydd respectively, but just as important an encounter will be between Dunvant and Banwen at Broadacre and second-placed Cwmllynfell are the visitors at Pontyberem.
In the East, new leaders Ystrad Rhondda go to Tredegar with a three-point lead over four chasing clubs, who include two of them - Treherbert and Nerwport Saracens - who meet up at Tynewydd Park.
Wales reached their first semi-final since 2013 in the opening round of this season's HSBC World Rugby Sevens Series in Dubai. WRU TV's Graeme Gillespie recaps on what proved to be an eventful tournament
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series