Top club Maesteg entertain second-placed Glamorgan Wanderers at Llynfi Road, just a week after some surprising results in this division.
Brynmawr's match against Whitland is in grave doubt as Brynmawr are scratching for a side, having failed to appear at Llangennech last Saturday, but one of the best matches could be at Tonmawr, who have former Wales tourist Lennie Woodard on their staff and entertain the very lively young Beddau team, who have Brett Davey doubling as fly half and coach.
Division Two. Leading match in the East involves Newport Saracens and Rumney at the Civil Service Ground. These are two of the four clubs on 21 points with the other two being Ystrad Rhondda and Abercynon. While strad are at home to Merthyr, Abercynon will face a trip to Croesyceiliog.
In the West, Cwmllynfell, in second spot, face tough opponents in Kidwelly, while leaders Waunarlwydd are at home to Pencoed and third and fourth meet when Banwen are opposed by Corus.
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s