Top club Maesteg entertain second-placed Glamorgan Wanderers at Llynfi Road, just a week after some surprising results in this division.
Brynmawr's match against Whitland is in grave doubt as Brynmawr are scratching for a side, having failed to appear at Llangennech last Saturday, but one of the best matches could be at Tonmawr, who have former Wales tourist Lennie Woodard on their staff and entertain the very lively young Beddau team, who have Brett Davey doubling as fly half and coach.
Division Two. Leading match in the East involves Newport Saracens and Rumney at the Civil Service Ground. These are two of the four clubs on 21 points with the other two being Ystrad Rhondda and Abercynon. While strad are at home to Merthyr, Abercynon will face a trip to Croesyceiliog.
In the West, Cwmllynfell, in second spot, face tough opponents in Kidwelly, while leaders Waunarlwydd are at home to Pencoed and third and fourth meet when Banwen are opposed by Corus.
Glyncoch have had a remarkable past couple of seasons, having lost just once in the last two seasons. Their fine form has been capped by claiming the South Central Division 5 crown of the SWALEC League.
With two rounds of the HSBC Sevens World Series remaining, Wales head coach Paul John has sprung a few surprises for this week's penultimate round in Glasgow. And there's still plenty to play for with World Cup spots on the line.