Llanelli go to Llanharan for a Saturday evening game, which on form should go to the men in red, but coach Dennis John will be hoping that his fit, young side can snatch a rare win. A Llanelli victory can bring them level at the top on 42 points. However, Neath are already 24 tries ahead of the Scarlets.
Ebbw Vale will be trying to avoid passive scrums when they entertain Swansea with Jason Williams having last week become the first man to reach 3.000 league points in a career when his 16 against Carmarthen Quins took him to 3,003 while Byron Hayward, his club colleague, has already overhauled Neil Jenkins into second place.
Cross Keys return to action in a derby against Pontypool, while a rejuvenated Newbridge after coach Mike Watkins cracked the whip, travel to meet an Aberavon side that has won six successive matches under new coaches Kevin Hopkins and Mark ones, both former Wales teammates.
Carmarthen Quins, who have lost four of their last five outings, take on Pontypridd, who gained a good 36-22 win over Cardiff last Saturday and Bedwas look for only their second home win of the season as they entertain a slightly off-colour Llandovery.
In the final match, Newport face bottom club Caerphilly at Rodney Parade. Odds are very much on the third-placed Black and Ambers, but it was only a few seasons ago that they lost five successive matches to Caerphilly
A special video package as Pontypridd claimed the double for the first time in their history by winning the Principality Premiership final, including match build-up, highlights, post match reaction and dressing room celebrations.