Llanelli go to Llanharan for a Saturday evening game, which on form should go to the men in red, but coach Dennis John will be hoping that his fit, young side can snatch a rare win. A Llanelli victory can bring them level at the top on 42 points. However, Neath are already 24 tries ahead of the Scarlets.
Ebbw Vale will be trying to avoid passive scrums when they entertain Swansea with Jason Williams having last week become the first man to reach 3.000 league points in a career when his 16 against Carmarthen Quins took him to 3,003 while Byron Hayward, his club colleague, has already overhauled Neil Jenkins into second place.
Cross Keys return to action in a derby against Pontypool, while a rejuvenated Newbridge after coach Mike Watkins cracked the whip, travel to meet an Aberavon side that has won six successive matches under new coaches Kevin Hopkins and Mark ones, both former Wales teammates.
Carmarthen Quins, who have lost four of their last five outings, take on Pontypridd, who gained a good 36-22 win over Cardiff last Saturday and Bedwas look for only their second home win of the season as they entertain a slightly off-colour Llandovery.
In the final match, Newport face bottom club Caerphilly at Rodney Parade. Odds are very much on the third-placed Black and Ambers, but it was only a few seasons ago that they lost five successive matches to Caerphilly
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series