The Dragons go into the match as the only Welsh region with a Heineken Cup victory this season - and they know a loss to the powerful French side will be a huge blow to their country's hopes of having a team in the last eight.
If all four of the Welsh regions fail to qualify for the knock-out stages it would be the first time Wales have missed out on a place in the quarter-finals in the 10-year history of the tournament.
"If we lose, it's going to be tough to qualify," Anderson admitted. "It would mean we have to go to Perpignan and win and also beat Newcastle up there - and then hope the other results go our way."
The former Australian rugby league coach says his side have to compete up front on Saturday, or they'll come second to a Perpignan side renowned for its powerful pack.
"I've seen a bit of Perpignan on video and they're a fair side," Anderson said. "They have a big, strong pack of forwards and there will be plenty of intensity in the match. I've seen a bit of their fly-half Manny Edmonds in Australia and he's a fair player.
"We know that if we can match them up front, we've got the firepower out wide to do some damage and score some tries."
The Dragons have slipped to fourth in the Celtic League after three losses on the bounce, and Anderson can't wait to get his international players back on board.
Wales players Gareth Cooper, Luke Charteris, Ceri Sweeney, Hal Luscombe, Steve Jones, Kevin Morgan and Michael Owen have all been in camp during the autumn Test series, while Springbok star Percy Montgomery has also been on international duty.
"It's been a good challenge lately, but it's a bit tough playing against sides with a lot of Australians and South Africans in there," Anderson said. "It's a real test of your playing depth, but we had chances to win all three of those games.
"It'll be good to see the Wales blokes again. I haven't seen them this week yet, but it looks like the only injury concern is Luke Charteris."
The sky-scraping second-rower injured a toe in his Test debut against South Africa earlier this month, but is on the road to recovery.
"I'd like to have Luke if we could - he's a good athlete. He has a lot of promise, but needs to get some consistent rugby into him."
Anderson is counting on the Dragons' 16th man - a packed Rodney Parade - to give his side a boost.
"We should get a good crowd," he said. "It's an important game and it's going to be a good game."
Welsh players and management joined Deputy Minister for Sport Ken Skates at the Pierhead Building, Cardiff Bay earlier this week to reveal the Union's pioneering school-club hub initiative has been so successful the project will now almost double the scale of the original project.
The Scarlets, Newport Gwent Dragons, Cardiff Blues and the Ospreys look ahead to Judgement Day III which sees the Blues take on the Ospreys (2.30) and the Dragons tackle the Scarlets (4.45pm) at the Millennium Stadium tomorrow afternoon.
Ystradgynlais and Ynysddu played out a titanic struggle at Taffs Well in the SSE SWALEC Bowl semi-final. At the end of the game neither team could be separated after a 15-15 stalemate but Ystradgynlais go through on try count.
Blues strike first in JD III battle - Newport Gwent Dragons lock Andrew Coombs, WRU referee Dylan Llyr Jones and Cardiff Blues hooker Matthew Rees decide dressing room allocations for Judgement Day III
Wales Under 18 captain Calum Haggett has received a conditional offer to read Biomedical Science at St Anne's College, Oxford. WRU chairman Gareth Davies went to meet Calum and Coleg y Cymoedd Principal Judith Evans to wish him luck in his exams and pass on some of his personal experience.
Dodgy tattoos, carthorses, Avatar and soft chins are revealed by Wales Sevens players Tom Williams and Sam Cross as they profile the Wales Sevens squad taking part in Hong Kong this weekend in the latest round of the HSBC Sevens World Series.