The Dragons go into the match as the only Welsh region with a Heineken Cup victory this season - and they know a loss to the powerful French side will be a huge blow to their country's hopes of having a team in the last eight.
If all four of the Welsh regions fail to qualify for the knock-out stages it would be the first time Wales have missed out on a place in the quarter-finals in the 10-year history of the tournament.
"If we lose, it's going to be tough to qualify," Anderson admitted. "It would mean we have to go to Perpignan and win and also beat Newcastle up there - and then hope the other results go our way."
The former Australian rugby league coach says his side have to compete up front on Saturday, or they'll come second to a Perpignan side renowned for its powerful pack.
"I've seen a bit of Perpignan on video and they're a fair side," Anderson said. "They have a big, strong pack of forwards and there will be plenty of intensity in the match. I've seen a bit of their fly-half Manny Edmonds in Australia and he's a fair player.
"We know that if we can match them up front, we've got the firepower out wide to do some damage and score some tries."
The Dragons have slipped to fourth in the Celtic League after three losses on the bounce, and Anderson can't wait to get his international players back on board.
Wales players Gareth Cooper, Luke Charteris, Ceri Sweeney, Hal Luscombe, Steve Jones, Kevin Morgan and Michael Owen have all been in camp during the autumn Test series, while Springbok star Percy Montgomery has also been on international duty.
"It's been a good challenge lately, but it's a bit tough playing against sides with a lot of Australians and South Africans in there," Anderson said. "It's a real test of your playing depth, but we had chances to win all three of those games.
"It'll be good to see the Wales blokes again. I haven't seen them this week yet, but it looks like the only injury concern is Luke Charteris."
The sky-scraping second-rower injured a toe in his Test debut against South Africa earlier this month, but is on the road to recovery.
"I'd like to have Luke if we could - he's a good athlete. He has a lot of promise, but needs to get some consistent rugby into him."
Anderson is counting on the Dragons' 16th man - a packed Rodney Parade - to give his side a boost.
"We should get a good crowd," he said. "It's an important game and it's going to be a good game."
Wales 7s captain Luke Treharne may have only played once on the World Series, but he has full confidence in his side as they prepare for the opening two rounds of this year's series in Dubai and South Africa, as WRU TV's Graeme Gillespie discovers.
Wales 7s Manager Steff Thomas believes Luke Treharne has all the attriubutes to be a top class captain. WRU TV's Graeme Gillespie hears his reasons why as the squad prepare for the opening two legs of the new World Series in Dubai and South Africa.
The British & Irish Cup kicks off this weekend with the four Regional Premiership Select XVs flying the flag for Wales. Welsh
Sat 14 Nov: Blues Premiership Select v Nottingham (2.30) & Connacht Eagles v Dragons (2.30)
Sun 15 Nov: Yorkshire Carnegie v Ospreys Premiership Select (1.30) & Scarlets v Bedford Blues (3.00)
The Welsh Rugby Union is forming a new Youth Board with a brief to help keep more young people involved in the game during their late teenage years and beyond. The first task of the fifteen strong Board will be to analyse and consider the issues which lead to a number of youngsters drifting away from the sport between the ages of 16 and 21. To apply visit www.wru.wales/youthboard
The Foster's Challenge Cup will involve the 12 Principality Premiership sides and will run during European and British & Irish Cup weeks, providing vital fixtures for the participating clubs and an opportunity for upcoming players to step up to semi-professional rugby and make a claim for starting places within the Premiership squads.
Eighty schools and colleges in Wales now have a full time rugby officer as part of the WRU's school club hub scheme. All of the school club hub officers recently gathered at the National Centre of Excellence for various workshops.
With Liam Williams forced out of the World Cup through injury, lock Luke Charteris and Skills Coach Neil Jenkins say they have to put yesterday's defeat behind them as Wales now look ahead to another physical encounter against South Africa in the quarter-finals of the Rugby World Cup.
WRU Consultant Head of Physical Performance Paul Stridgeon praises the Physical Performance department for their work and dedication as he addresses the media ahead of Wales' Pool A clash against Australia
Twelve young people have been selected to follow a one year WRU Coach Core apprenticeship programme. Coach Core was set up by the Royal Foundation of the Duke and Duchess of Cambridge and Prince Harry as part of the Olympics legacy in 2012 and the Duke of Cambridge was on hand to meet the apprentices on their first day in the job. The programme has been funded by the Hunter Foundation.