Every club in the West has lost at least one match this season, making it a very close division and the top match is likely to be at Neyland, where both they and visitors Fishguard are on 12 points, along with three other clubs.
Crumlin are the surprise package in the East, but they play at an in-form Pontllanfraith in what should be a cracker of a match and Newport HSOB are likely to find Tredegar Ironsides a tough side to beat, while Monmouth will be hard pressed to take points at Oakdale.
Aberdare will meet determined opponents in Llandaff in the South-East, though joint leaders Fairwater will prove a hard side for home club Llantwit Major to defeat.
Biggest match in Division Three is likely to be at Briton Ferry, where both they and visitors Resolven have won all five matches thus far. Tonna can make up ground if they overcome a game Ystradgynlais side.
Llangefni sit it out in the North and as a result could see their lead at the top vanish as Mold go to Colwyn Bay with an unbeaten tag when a win will take them to the top.