Senghenydd and Bargoed meet in the East Division's match of the day as both clubs are unbeaten. For newly-promoted Bargoed it has been an exceptionally good start, while Rhymney, relegated last season also have strong fixture at home to the David Bishop-coached Old Illtydians from Cardiff.
Gorseinon took a chance last week with league and cup games, eventually defeating Trimsaran in the West Division, but going out of the cup.
They take their unbeaten league record to Aberystwyth, who also have not dropped a point. Both Loughor and Pembroke Dock Quins have also 100% records.
In the South-East, top dogs Mountain Ash go to Penygraig in the hope that the home side will field this week, while Rhydyfelin entertain Tonyrefail and Pentyrch face the might of Gilfach Goch.
The three unbeaten clubs of the South-West, Vardre, Bryncoch and Skewen all have home games, against Kenfig Hill, Nantyffyllon and Aberavon Quins respectively.