Neath are the only unbeaten club, but trail Newport by three points though they have a 29-24 try-count on their rivals. Cross Keys upset Newport in the cup last season and will no doubt have a hot welcome for their former coach Dai Rees.
Cardiff will find it difficult to get on winning ways as they meet Bridgend at the Brewery Field and Llanelli could well perish at Pontypool Park, where the home side are finishing matches at high speed.
Llanharan are given everything for coach Dennis John and could prove difficult for Carmarthen Quins at the Dairy Field, while Aberavon, after a win over Swansea, will find Ebbw Vale no pushovers at Eugene Cross Park.
Llandovery will provide a hot welcome for out-of-form Newbridge at Church Bank and bottom club Caerphilly go to Swansea in the knowledge that they did the treble last season, winning twice in the league and once in the cup.