Crumlin are the surprise leaders of the East and hope to carry on that way after playing against Cardiff HSOB, while four clubs could catch them if they should lose that match, with Chepstow and Tredegar Ironsides likely to prove the top game.
Everyone has lost at least one match in the West with four clubs having five wins each and the main game likely to be between Cefneithin and Laugharne.
The two unbeaten South-East clubs are both favourites to win again with Aberdare at Cowbridge and Fairwater at home to Llantwit Major, while Penarth visit Dowlais.
In the South-West, leaders Resolven take on Heol y Cyw, but the game of the day could be at Tonna, where Briton Ferry are the visitors.
Only old remain unbeaten in the North, though they have drawn twice. They will entertain Llangefni, who have 12 points along with Caernarfon and Llandudno, who are both away at Denbigh and Pwllheli respectively.