Top clubs Monmouth and Crumlin face tough tasks in the East as Crumlin go the Harlequins Ground where St Peter's are almost ready to unveil their new clubhouse and Monmouth go away to face Tredegar Ironsides.
Only Laugharne and Fishguard remain unbeaten in the West and while Laugharne entertain Neyland, who scratched from the cup last week, Fishguard have an away match at Gowerton, who have yet to pick up a point.
In the South-East, Fairwater take their strong squad to Rhigos, who also scratched from the cup, while Aberdare face Bedlinog and an improving young Penarth team are hosts to struggling Pontyclun.
Resolven's smart start in the South-West may face problems away to Aberavon Green Stars, who have Chris O'Callaghan as the Director of Coaching, Tonna face a stern test away to Maesteg Celtic and Briton Ferry are at home against Heol y Cyw.
In Four North, Llandudno are the bye club and the other unbeaten club are Mold, who play only their third match as they visit Pwllheli.