Brynmawr have scratched at Narberth and Wrexham will not be travelling south to Bonymaen, allowing those two home clubs to not only meet in a rearranged Division One game, but also have free access to the last 64 in Round Three.
Of the 90 clubs due to be played, Trefil are the only non-leaguer side remaining and they have a splendid tie at home to Three South-West leaders Bryncoch in prospect.
North Wales will see Dolgellau at home to Crymych and Nant Conwy entertaining powerful Cwmllynfell, while Bethesda are due a hard match at Llangennech and Colwyn Bay travel to Pembroke Dock Quins.
Two others are away with Llangefni at Senghenydd and Denigh appearing at UWIC in a very hard encounter.
One of the best ties could be at Aberystwyth,. where Glamorgan Wanderers break new ground and Bailey Park Abergavenny will see Abercynon as visitors.
Carmarthen Athletic face a hard match at Crumlin and the Corus-Dunvant all-Division Two game will be a cracker.
Llanishen prepare for powerful Maesteg Quins on their Usk Road pitch and the Llantwit Fardre-Felinfoel tie will be close, while Blackwood have a potential banana-skin at Llantrisant, where the Black Army awaits them.
The splendid Mountain Ash pitch will be a tester for a young Penarth outfit while Penallta against Cefn Coed is a close call; Pontycymmer against Bridgend Athletic is a derby and Rumney versus Rhymney brings a tongue-twister.