Leaders Bala visit one of their closest rivals Bethesda in the top match of the North, with Llanidloes likely to pounce if Bala lose and they defeat bottom club Bangor.
Nantyglo should keep their lead in the East as they entertain Blaenavon, while the beautiful Abertillery Park is the setting for the newly-formed Abertillery BG side's match against Machen.
Pace-setters Aberaeron and Penygroes both are away in the West, but are expected to gain full points with Pembroke having won all four matches, but still being just off the pace. They entertain bottom club Llanybydder.
Porth against Cilfynydd is certainly the biggest clash in the South-East as both have four wins and a draw from five outings, but Penallta, who visit Blaengarw, are the division's highest scorers.
Unbeaten Crynant face a huge test at Birchgrove in the South-West, while Abercrave, also with five straight wins, take on the dangerous Glyncorrwg side, who are the new boys in this group.