Ospreys trio Huw Bennett, Andy Lloyd and Luke Tait will all miss the start of the Celtic League campaign against Munster this weekend.
Wales hooker Bennett, who toured Argentina and South Africa in the summer, is suffering a hernia and could also miss the west Wales derby against Llanelli a week later.
Flanker Lloyd is also out for a fortnight with a hamstring problem while coach Lyn Jones is also keeping a close eye on lock Tait's neck strain.
'It's a blow but we have brought in a number of high-quality players to strength in depth to the the squad,' said Jones.
Meanwhile the Ospreys are considering a change in team name and playing colours for next season as they quiz supporters from Neath and Swansea over the future of the regional team.
Ospreys chief executive Andrew Donald said: 'The consultation will be exactly that - a listening exercise. We want to know from supporters what they think we've got right and where we could do better. We'll want to know what they think of the Ospreys' identity and branding, as well as obtain feedback on the Ospreys' future facilities.'
GB7s women left their England base to train in Wales this week. Olympic Games hopeful Rachael Burford gives WRU TV's Graeme Gillespie her thoughts on Welsh teammate Jasmine Joyce - a 'one touch wonder'
The GB7s women's squad is currently training at Wales' Centre of Excellence where assistant coach Richie Pugh tells WRU TV's Graeme Gillespie some 'tough calls' will have to be made when it comes to finalising the 12 spots for Rio's Olympic Games.
Wales U20's Billy McBryde is looking forward to starting his first game against New Zealand this afternoon in the World Rugby U20 Championship where his side are looking to gain revenge from last week's pool defeat to the Kiwis.