Old Illtydians get back to action in the East when leaders Brynithel are the attractive visitors to Llanrumney Park and not too far away, Pill Harriers have their big fixture against local opponents, Newport Saracens.
Pontyberem face a hard match against Lampeter in the West, where Kidwelly go to Tumble and Haverfordwest go to Aberystwyth. The big match in the South-East is between the top clubs Nantymoel and Gilfach Goch, where Nantymoel hold a three-point lead.
Treherbert hope to get their act back with a win over Pentyrch. Banwen should hold the South-West lead with a win away to Ystrradgynlais and Maesteg Quins entertain Skewen.
Bargoed have an eight-point lead in the East as they travel to the Harlequins Ground to meet St Peter's, while Blaina visit Tredegar Ironsides and Monmouth take on Cardiff HSOB.
In the West, Loughor take on Llandybie and Laugharne face tough opponents in Burry Port. South-East leaders Abercwmboi face new visitors in Penarth, while Fairwater meet Old Penarthians, now the bottom club, and Pontycymmer visit Cefn Coed.
In the South-West, lltwen face a hard match at Rhigos, Briton Ferry go to Abercrave and leaders and leaders Taibach are at Amman United. Northern cup-fighters Llangefni make the trip to Pwllheli, but the leading pair - Ruthin and Nant Conwy - are both at home, against Wrexham
and Bala respectively.
The battle for the East title looks to be between Trinant and Oakdale and both have away matches - Trinant at St Alban's in Tremorfa Park and Oakdale go to Nantyglo.
Cefneithin have what seems an easy home game against Llangwm in the West and second-placed Crymych are also home, against St Clears. South-East leaders Llandaff face a difficult match at Waterton Cross against South Wales Police, while Llandaff North meet Ogmore Vale at Hailey Park and Llantwit Major come up to Lawrenny Park to take on Canton.
In the South-West, Resolven and Aberavon Green Stars both seem to have sure away wins at Pontardawe and Swansea Uplands respectively, while Crynant entertain Porthcawl.
In Five North, leaders Denbigh travel to Rhos and Colwyn Bay go to Bro Ffestiniog, while both
Llanidloes and Bangor University look for their first wins of the season.