East leaders Brynithel and second-placed Llanishen are both at home, but the top clash would appear to be Senghenydd against fast-improving Cwmbran. The West will see home matches for Haverfordwest and Kidwelly, but Pontyberem are away to Llandeilo. In the South-East there is a tough match for leaders Treherbert, at home to Mountain Ash, while improving Nelson take on Nantymoel.
The South-West will see Banwen have a hard match in store against Mumbles, as Maesteg Quins are at home against Ystradgynlais.
East leaders Bargoed entertain Crumlin, knowing that Blaina are without a fixture, but the big clash will be at Chepstow where Monmouth are the visitors. Chepstow's away win was deleted by an appeals committee and Monmouth have since overtaken them.
In the West, Loughor look capable of picking up a result away to third-placed Pembroke Dock quins, while Llanelli Wanderers take on Laugharne. Abercwmboi appear to have a good chance of the points in the South-East as they travel to bottom club Bedlinog, while Fairwater are away in a hard task at Aberdare. South-West may see a change at the top if Alltwen falter at Cefn Cribbwr and Taibach win at home to Glais, while bottom club Maesteg Celtic look for a home win against Rhigos. North leaders Ruthin will face a severe test at third-placed Caernarfon, which may see second club Nant Conwy close up if they gain aq home win over Dolgellau.
Match of the day in this division must be in the West when leaders Cefneithin travel to second-placed Crymych, though even a home win would keep Cefneithin six points clear. Llantwit Major get the chance to close an eight-point gap in the South-East when they travel to Rhiwbina, but leaders Llandaff take the day off.
Trinant have the chance to pull further away in the East as they entertain Bettws and Oakdale have a bye. In the North, Denbigh go to Bro Ffestinion and Colwyn Bay travel to Machynlleth, while in the South-West the top clubs are at home with Aberavon Green Stars entertaining Neath Athletic and Resolven taking on Baglan.