The unbeaten pair of Maesteg and Llanharan both face away matches with the Old Parish going to Beddau and Llanharan making the short trip to Glamorgan Wanderers. Rumney hope to catch Whitland on a slippery pitch, though it will be played at Cardiff University's ground, as their own Riverside Park is waterlogged.
Narberth should be pressed all the way at Blackwood and coach Arwel Davies will certainly realise that Llangennech will face a forward battle if the Brynmawr pitch is playable.
There must be doubts over Tredegar's match against Carmarthen Athletic after a hole developed in the pitch last month, while Treorchy face bottom club Tondu, who have already conceded over 1,000 points and UWIC's match with Bonymaen should produce much free-flowing rugby.
West leaders Dunvant will hope for a return to form and that visitors Aberavon Quins will be able to field against them, while second-placed Cwmllynfell must also hope to get back on the winning trail in a difficult match away to Bridgend Athletic.
Corus will be hard opponents for Cardigan while Vardre hope to spring a shock at Felinfoel. In the East, the Fleur de Lys-Abercynon encounter will be worth watching, with leaders Merthyr without a match and Builth Wells able to go top if they win at Rhymney.