None of the leaders in the four sections of this division are in opposition, but there could still be changes at the top in the East and South-East.
Brynithel, top the East, but have to get back into form quickly at Abercarn if they want to hold off Llanishen, who have a local derby in Cardiff, away to the Old Illtydians.
Nantymoel need to come away from Taffs Well with a win in the South-East, but victory is far from sure for nearest rivals Gilfach Goch, who have a tricky match away to Brecon, in a division where Treherbert versus Nelson could be a fine game.
Pontyberem top the West and have Trimsaran at home, while Kidwelly visit Pontarddulais and Haverfordwest are home to Lampeter.
In the South-West, leaders Banwen visit Brynamman, while Maesteg Quins have a tough task at Nantyffyllon.
Match of the day in this section is the Abercwmboi-Fairwater battle in the South-East, as Abercwmboi hold a three-point lead, but have played three matches more than their Cardiff-based opponents.
Bargoed are within sight of the East title and should defeat St Joseph's at home, while Blaina meet Pontllanfraith at Central Park.
There is no match for North leaders Ruthin as scheduled opponents Llangefni are still in the Cup. This will enable Nant Conwy to close the gap if they win away to Mold.
The Llanelli Wanderers-Lladybie match will have a big bearing on the West title as Loughor and Pembroke Dock quins have home matches against Milford Haven and Burry Port respectively.
In the South-West, Taibach could retake the lead if they defeat Maesteg
Celtic and Briton Ferry go down away to Amman United, while both Alltwen and Cwmgors are playing away.
A draw between Gwernyfed and Oakdale could be the best scenario for East leaders Trinant, who travel to in-form Garndiffaith, while in the West, Cefneithin look good to keep at least an eight-point lead as they take on Pontyates and both Crymch and Pembroke are also playing at home.
South-East leaders Llandaff have the toughest of their three remaining match, as they travel down the road to meet Llandaff North at Hailey Park, while Llantwit Major are at Cilfynydd.
North's top pairing of Denbigh and Colwyn Bay have away matches that they should win, while in the South-West, Resolven go to Cwmtwrch and Aberavon Green Stars are in Pontardawe, but the big clash could be at Crynant, where Tonna are the visitors.