Banwen against Maesteg Quins is the top match in the South-West and the Quins know they have to shorten the Banwen five-point lead, though there is a game in hand to the Maesteg outfit. Equally as important is Kenfig Hill's match against Mumbles.
Brynithel hope to stay ahead of the East after meeting Pill Harriers with the top runners all in home matches, while in the West there are away games for Pontyberem (at Hendy) and Haverfordwest (at Penclawdd), though Kidwelly will hope to move up after playing home against bottom club Gowerton.
In the South-East, Nantymoel face the dangerous Tonyrefail and Gilfach Goch host Taffs Well, while other interesting matches are Nelson against Mountain Ash and Rhydyfelin at home to Brecon.
Eastern leaders Bargoed are favourites to keep a 11-point lead over Blaina when they entertain Ynysddu, though Blaina travel to St Joseph's if the Cardiff Parks are available.
In the West Loughor, Pembroke Dock Quins, Llanelli Wanderers and Laugharne are the top four clubs and all face away matches, while South-West leaders Briton Ferry face second-placed Taibach with just a point seperating them after 16 matches.
Once again, both Penarth-based clubs are at home with Old Penarthians facing Abercwmboi. Fairwater will hope the local parks are playable for their match against Heol y Cyw. In the North, leaders Ruthin go to Rhyl, Nant Conwy entertain Newtown and Bala hope for their first win at home to Wrexham.
While Eastern leaders Trinant are at home to Nantyglo, Cefneithin take their eight-point lead in the West away to Penygroes and in the North Denbigh face a useful Bethesda side, while Colwyn Bay entertain Welshpool.
Resolven face a hard match against Crynant in the South-West; Aberavon Green Stars entertain Cwmgwrach and Tonna hope to progress against Pontardawe. In the South-East Llandaff lead with only four matches rwemaining and they will hope to face Cilfynydd at Bishop's Field, while Llantwit Major should have a tight match against South Wales Police and Llandaff North may have to kick their heels
Rhiwbina if that match is washed out.