Parker suffered a leg strain in training earlier this week and will be resting over the weekend in order to resume full training on Monday.
Mark Taylor has been called into the match-day squad to take up Parker's position on the replacements bench.
Wales: G Thomas (Toulouse, capt), R Williams (Blues), T Shanklin (Blues), G Henson (Ospreys), H Luscombe (Dragons), S Jones (Clermont-Auvergne), D Peel (Scarlets), G Jenkins (Blues), M Davies (Neath), A Jones (Ospreys), G Llewellyn (Narbonne), L Charteris (Dragons), D Jones (Scarlets), C Charvis (Newcastle), M Owen (Dragons)
Replacements: S Jones (Dragons), D Jones (Ospreys), J Thomas (Ospreys), M Williams (Blues), G Cooper Dragons), C Sweeney (Dragons), M Taylor (Scarlets)
Romania: V Maftei (Aurillac), V Ghioc (Dinamo Bucuresti), C Sauan (Rugby Rovigo), R Gontineac (Aurillac), I Teodorescu (U Cluj), I Tofan (Metro Racing), L Sirbu (Metro Racing), P Balan (Biarritz Olimpique), B Zebega (Steaua Bucuresti), M Socaciu (Rugby Rovigo), F Tatu (Steaua Bucuresti), C Petre (Tarbes), C Mersoiu (Perigueux), MA Tudori (Perigueux), A Petrache (Beziers, capt)
Replacements: R Mavrodin (Tarbes), B Balan (Bordeaux Begles), V Ursache (Contor Zennerarad), G Oprisoror (Perpignan), I Andrei (Steaua Bucharest), F Dobre (Dinamo Bucharest), I Dimofte (Contor Zennerarad)
Referee: Kelvin Deaker (New Zealand)