Division Three Top club Bargoed in the East will travel to bottom club Talywain knowing that they already lead the division by five points and that Abergavenny face a difficult game at Blaina. In the South-East there is probably the top game of the four areas as the unbeaten clubs of Rhydyfelin and Mountain Ash meet up, though the Old Firm will be without a few regulars in their back division. Also in the South-East, Ruthin will provide the interesting opposition for Barry at the Reservoir Field.
Loughor take their unbeaten tag in the West to Penclawdd, while leaders Gorseinon also travel, going to Llandeilo, but the closest game could be between Pembroke Dock Quins and Aberystwyth at the Bierspool Ground.
Brynoch hope to bounce back from defeat by Maesteg Quins as they take on Kenfig Hill in the South-West. The Mules are among six clubs who are just three points behind Banwen, though none of them will meet.
Division Four Resolven, runaway leaders of the South-West, face second-placed Tonna on Vaughan Field with all the other clubs hoping for an away win. Just as important is the game at Fishguard in the West as the fifth-placed Seagulls face leaders Amman United with Neyland, home to Llandybie, and Cefneithin, away to Milford Haven, awaiting the Amman result.
Both unbeaten clubs, Fairwater and Aberdare, in the South-East, would feel confident of gaining victories as The Snakes travel to Dowlais and Fairwater face Cowbridge at Ashcroft Park. An interesting battle will be on the Athletic Field as Penarth entertain Llantwit Major.
North leaders Llangefni face a trip to Parc Bodegroes to take on Pwllheli, but second-placed Colwyn Bay will find Llandudno a difficult task at Maesdu Recereation Ground, while third-placed Mold are at Chester Road against Caernarfon.
The two unbeaten clubs of this division will both be at home as Nantyglo face on second-placed Machen at Banna Park in the East and Pembroke take on Penygroes at Crickmarren Field in the West.
The East will see the meeting of the Cardiff-based Saints with St Joseph's facing St Alban's on Blackweir, while Llanybydder, with nine straight losses, go in hope to end that run at St David's.
While South Wales Police face Bridgend Sports at Waterton Cross, the big match of the South-East is at Cefn Coed's Black Patch, alias Cae Rhodd Evan, where high-flying Porth are the visitors.
Four clubs are on 21 points in the South-West, but none of them meet up as Birchgrove, Crynant and Glyncorrwg are away and Abercrave face Cwmgwrach at Plas y Ddol.
In the North, leaders Bala are at home to Welshpool and Bethesda will be at Dol Dafydd against a useful Llanidloes side.
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s