Division Three Top club Bargoed in the East will travel to bottom club Talywain knowing that they already lead the division by five points and that Abergavenny face a difficult game at Blaina. In the South-East there is probably the top game of the four areas as the unbeaten clubs of Rhydyfelin and Mountain Ash meet up, though the Old Firm will be without a few regulars in their back division. Also in the South-East, Ruthin will provide the interesting opposition for Barry at the Reservoir Field.
Loughor take their unbeaten tag in the West to Penclawdd, while leaders Gorseinon also travel, going to Llandeilo, but the closest game could be between Pembroke Dock Quins and Aberystwyth at the Bierspool Ground.
Brynoch hope to bounce back from defeat by Maesteg Quins as they take on Kenfig Hill in the South-West. The Mules are among six clubs who are just three points behind Banwen, though none of them will meet.
Division Four Resolven, runaway leaders of the South-West, face second-placed Tonna on Vaughan Field with all the other clubs hoping for an away win. Just as important is the game at Fishguard in the West as the fifth-placed Seagulls face leaders Amman United with Neyland, home to Llandybie, and Cefneithin, away to Milford Haven, awaiting the Amman result.
Both unbeaten clubs, Fairwater and Aberdare, in the South-East, would feel confident of gaining victories as The Snakes travel to Dowlais and Fairwater face Cowbridge at Ashcroft Park. An interesting battle will be on the Athletic Field as Penarth entertain Llantwit Major.
North leaders Llangefni face a trip to Parc Bodegroes to take on Pwllheli, but second-placed Colwyn Bay will find Llandudno a difficult task at Maesdu Recereation Ground, while third-placed Mold are at Chester Road against Caernarfon.
The two unbeaten clubs of this division will both be at home as Nantyglo face on second-placed Machen at Banna Park in the East and Pembroke take on Penygroes at Crickmarren Field in the West.
The East will see the meeting of the Cardiff-based Saints with St Joseph's facing St Alban's on Blackweir, while Llanybydder, with nine straight losses, go in hope to end that run at St David's.
While South Wales Police face Bridgend Sports at Waterton Cross, the big match of the South-East is at Cefn Coed's Black Patch, alias Cae Rhodd Evan, where high-flying Porth are the visitors.
Four clubs are on 21 points in the South-West, but none of them meet up as Birchgrove, Crynant and Glyncorrwg are away and Abercrave face Cwmgwrach at Plas y Ddol.
In the North, leaders Bala are at home to Welshpool and Bethesda will be at Dol Dafydd against a useful Llanidloes side.
Wales and Ospreys back row James King, who came through the North Wales age grade system, nominated North Wales Regional Community Rugby Manager Marc Roberts, in the WRU's 'Diolch' initiative where squad players thanked those who played a part in their rise to the top.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
When the Wales squad were asked to nominate individuals who played a big part in their early playing days, Wales and Dragons full back and wing Hallam Amos thought of his former Monmouth School rugby coach John Bevan.
Sam Cross and Luke Treharne have been named as co-captains of the Wales Sevens side as head coach Gareth Williams names his 12-man squad to play in the first leg of the HSBC World Series in Dubai next weekend.
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
Many of the Wales squad have said Diolch (thank you) to someone who played an important part in their early playing days by nominating them to be invited to the Wales v South Africa match. One person, Gowerton Comprehensive geography teacher Mr Dean Mason was nominated by two of his former pupils, Dan Biggar and Sam Davies.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
WRU TV: Hear from inside the Wales camp as Neil Jenkins discusses this weekend's clash with South Africa and how the squad are looking to put in a strong performance to round of the 2016 Under Armour Series