Unbeaten records remained as both Fairwater and Aberdare in the South-East and Resolven in the South-West all won easily.
While Aberdare defeated ontyclun 60-19 and Resolven accounted for Trebanos 25-8 in home matches, Fairwater gained a powerful 52-19 victory at Bedlinog. Tonna hold second spot in the West after a 77-12 mauling of Pyle.
Monmouth held the lead in the East after three Leon Millard tries took them through by 18-17 at Cardiff HSOB, but Crumlin were upset at home by Trinant and Chepstow fell away to St Peter's.
In the West, Amman Utd won the big battle as they turned aside Neyland by 35-12 to take a three-point lead over their rivals, who were caught by Cefneithin, after the latter defeated Fishguard by 15-6.
Rugby in the North saw Llangefni have a good 40-6 win at home to Newtown and Colwyn Bay stayed in second place after beating Pwllheli 22-3.