The match of the season thus far is expected at the Gnoll when unbeaten leaders Neath take on last season's champions, Newport. Having had three points docked and losing at Ebbw Vale last week, Newport will see this as make or break to topple the Welsh All Blacks.
Just as interesting as the top match will be the Aberavon-Llanelli clash as the four-match run of the Wizards will be on the line against the ten-match winning streak of the second -placed Scarlets. Bedwas, without a home win, take on free-scoring Swansea and Ebbw Vale look for another home win as they face the speedy Cardiff back division.
While Cross Keys and Llandovery meet in a mid-table battle, there is a basement struggle at Llanharan where bottom club Caerphilly are the visitors in an important match. Other strongly-contested games will be between Bridgend against Pontypool and Pontypridd at home to Newbridge.
GB7s women left their England base to train in Wales this week. Olympic Games hopeful Rachael Burford gives WRU TV's Graeme Gillespie her thoughts on Welsh teammate Jasmine Joyce - a 'one touch wonder'
The GB7s women's squad is currently training at Wales' Centre of Excellence where assistant coach Richie Pugh tells WRU TV's Graeme Gillespie some 'tough calls' will have to be made when it comes to finalising the 12 spots for Rio's Olympic Games.
Wales U20's Billy McBryde is looking forward to starting his first game against New Zealand this afternoon in the World Rugby U20 Championship where his side are looking to gain revenge from last week's pool defeat to the Kiwis.