The match of the season thus far is expected at the Gnoll when unbeaten leaders Neath take on last season's champions, Newport. Having had three points docked and losing at Ebbw Vale last week, Newport will see this as make or break to topple the Welsh All Blacks.
Just as interesting as the top match will be the Aberavon-Llanelli clash as the four-match run of the Wizards will be on the line against the ten-match winning streak of the second -placed Scarlets. Bedwas, without a home win, take on free-scoring Swansea and Ebbw Vale look for another home win as they face the speedy Cardiff back division.
While Cross Keys and Llandovery meet in a mid-table battle, there is a basement struggle at Llanharan where bottom club Caerphilly are the visitors in an important match. Other strongly-contested games will be between Bridgend against Pontypool and Pontypridd at home to Newbridge.
The Welsh Rugby Union has awarded a unique 'President's Cap' to a specific group of players who represented their country between 1945 and 1979, but missed out on international recognition at the time.
Prabhat Mathema, the WRU's National Medical Manager explains the four part Pitchside Suspected Concussion Assessment process the IRB has devised that is being implemented throughout the Dove Men Series and in the LV= Cup this season, which includes the provision for a five minute temporary substitution to allow an assessment to take place.