The match of the season thus far is expected at the Gnoll when unbeaten leaders Neath take on last season's champions, Newport. Having had three points docked and losing at Ebbw Vale last week, Newport will see this as make or break to topple the Welsh All Blacks.
Just as interesting as the top match will be the Aberavon-Llanelli clash as the four-match run of the Wizards will be on the line against the ten-match winning streak of the second -placed Scarlets. Bedwas, without a home win, take on free-scoring Swansea and Ebbw Vale look for another home win as they face the speedy Cardiff back division.
While Cross Keys and Llandovery meet in a mid-table battle, there is a basement struggle at Llanharan where bottom club Caerphilly are the visitors in an important match. Other strongly-contested games will be between Bridgend against Pontypool and Pontypridd at home to Newbridge.
Nearly 40 players were involved in the first Wales Under 18 training session of the season. WRU National Performance Manager Gethin Watts is excited at the potential shown by the group and expects the Regional Under 18 Championship to hone their skills even further.