With fifteen of the 22 rounds played, the final third of the season is shaping nicely for a thrilling climax.
Ulster sit on top of the table with 48 points. A record of 10 wins from 15 games, followed by the Llanelli Scarlets (47) and The Dragons (44).
Click to read match previews on the Celtic League site
But the Celtic Cup winners travel to play the powerful Celtic Warriors region at the Brewery Field on Friday night.
The Warriors are fourth on 43 points and with only seven rounds left, Lynn Howells' men know a win in Bridgend this weekend will bring them right into contention. Ulster won their first-round clash 26-20.
The switch to regionalism has seen Welsh sides dominate the League table, with all five in the top seven on the competition.
With Heineken Cup spots next season the reward for the four leading Welsh sides, competition is red-hot as the Neath-Swansea Ospreys and the Cardiff Blues find some form after a slow start to the season.
The threat of relegation from the Cup will be at the front of everyone's minds when the Llanelli Scarlets take on the Blues at the Arms Park on Saturday night.
A loss will be a big blow to the Scarlets' title hopes, while the in-form Blues will be looking over their shoulders if they can't come away from the game with at least four points.
In other matches, Edinburgh host the Ospreys at Meadowbank on Friday night, while The Borders and Glasgow face off at Netherdale in a match that could decide who anchors the table this season. Glasgow won a thrilling first-round clash 26-25.
Defending champions Munster will looking to get their season back on track when they play The Dragons at Thomond Park, with Mike Ruddock's men desperate to prove they can perform away from their Rodney Parade fortress.
In the only Saturday afternoon game, Connacht host Leinster as both sides try to move into the top half of the table.
An added bonus for fans this weekend is the return of international players as the RBS Six Nations Championship takes a break.